Auriane destrument elucidating the role of mkk4 in neuronal apoptosis
The level of caspase-3 activation in neurons correlates inversely with the level of syn GAP protein measured at 2 and 8 weeks after birth, indicating that neuronal apoptosis is enhanced by reduction of syn GAP. (2005), A role for syn GAP in regulating neuronal apoptosis. These data show that syn GAP plays a role in regulation of the onset of apoptotic neuronal death. Homozygous deletion of syn GAP is lethal within the first few days after birth. Thus, Syn GAP may play an important role in coupling N-methyl-D-aspartate-type glutamate receptor activation to signaling pathways downstream of Ras or Rap.The present study investigated the protective effects of HSYA in rat spinal cord compression injury model and related mechanisms involved. Spinal cord injury (SCI) model was induced by application of vascular clips (force of 50 g, 1 min) to the dura at T9–T10 level of vertebra.
Unlike necrosis, apoptosis produces cell fragments called apoptotic bodies that phagocytic cells are able to engulf and quickly remove before the contents of the cell can spill out onto surrounding cells and cause damage to the neighboring cells.Necrosis is the premature death of cells and living tissue.Though necrosis is being researched as a possible form of programmed cell death, it is considered an "unprogrammed" cell death process at this time.Hydroxysafflor yellow A (HSYA) is a major active component of yellow pigment extracted from safflowers; this compound possesses potent neuroprotective effects both in vitro and in vivo.However, underlying mechanism of HSYA is not fully elucidated.